Nausea and vomiting in pregnancy guidelines

Review

ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy

Committee on Practice Bulletins-Obstetrics. Obstet Gynecol. 2018 Jan.

Abstract

Nausea and vomiting of pregnancy is a common condition that affects the health of a pregnant woman and her fetus. It can diminish a woman's quality of life and also significantly contributes to health care costs and time lost from work (1, 2). Because morning sickness is common in early pregnancy, the presence of nausea and vomiting of pregnancy may be minimized by obstetricians, other obstetric care providers, and pregnant women and, thus, undertreated (1). Furthermore, some women do not seek treatment because of concerns about the safety of medications (3). Once nausea and vomiting of pregnancy progresses, it can become more difficult to control symptoms. Treatment in the early stages may prevent more serious complications, including hospitalization (4). Safe and effective treatments are available for more severe cases, and mild cases of nausea and vomiting of pregnancy may be resolved with lifestyle and dietary changes. The woman's perception of the severity of her symptoms plays a critical role in the decision of whether, when, and how to treat nausea and vomiting of pregnancy. Nausea and vomiting of pregnancy should be distinguished from nausea and vomiting related to other causes. The purpose of this document is to review the best available evidence about the diagnosis and management of nausea and vomiting of pregnancy.

Comment in

  • ACOG Practice Bulletin 189: Nausea and Vomiting of Pregnancy.

    Erick M, Cox JT, Mogensen KM. Erick M, et al. Obstet Gynecol. 2018 May;131(5):935. doi: 10.1097/AOG.0000000000002604. Obstet Gynecol. 2018. PMID: 29683896 No abstract available.

  • In Reply.

    Ramin SM, Turrentine MA, Zahn CM. Ramin SM, et al. Obstet Gynecol. 2018 May;131(5):935-936. doi: 10.1097/AOG.0000000000002605. Obstet Gynecol. 2018. PMID: 29683897 No abstract available.

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What is the management of nausea and vomiting in pregnancy?

Eat snacks frequently and have multiple small meals (eg, six small meals a day) that are high in protein or carbohydrates and low in fat. Stick to a bland diet. Drink cold, clear, and carbonated or sour fluids (eg, ginger ale, lemonade) and drink these in small amounts between meals.

Does nausea and vomiting mean a healthy pregnancy?

Studies have shown that women with nausea and vomiting during the first trimester have a lower risk of miscarriage than do women without these symptoms. What's the connection? Nausea and vomiting during early pregnancy might indicate you are experiencing the climb in hormones needed for a healthy pregnancy.

What is the first line antiemetic in pregnancy?

Pyridoxine (vitamin B6) is used first-line in many countries for nausea and vomiting in early pregnancy, however, there are large individual differences in its onset and action. Studies have shown that pyridoxine improves mild to moderate nausea but does not significantly reduce vomiting.

What is the safest antiemetic for pregnancy?

Pyridoxine-doxylamine is still the only medication that the U.S. Food and Drug Administration has specifically labeled for the treatment of nausea and vomiting of pregnancy.